WebbIt was observed that micellar solutions of the surfactant obtained significantly improved the solubility of hydrophobic drugs with respect to pure water, by including these … Webb11 apr. 2024 · Therefore, various techniques such as pH modification , co-solvency , size reduction , self-emulsifying , usage of liposomes , polymers , and nanoparticles have been designed to improve the solubility of the poorly soluble drugs. Inadequate solubilization, higher critical micellar concentrations (CMC), and probable side effects following ...
Styrene Maleic Acid Copolymer-Based Micellar Formation of …
WebbHighly augmented drug loading and stability of micellar nanocomplexes comprised of doxorubicin and poly (ethylene glycol)-green tea catechin conjugate for cancer therapy Advanced Materials Feb... WebbDissolutionand solubility rates are very important parameters in designing a pharmaceutical dosage form, especially for oral drug administration. Oral drugs that … ritesh chopra
André Moreni Lopes - Professor - Universidade de São Paulo
WebbLecithin added was functioned to enlarge the hydrophobic core of MPMs providing greater solubilization capacity. Amphiphilic polymers (sodium deoxycholate [NaDOC], TPGS, CREMOPHOR, or a PLURONIC series) were examined for potentially self-assembling to form MPMs (saMPMs) with the addition of lecithin. WebbTo demonstrate controlled delivery of chemotherapeutic agents with DASA-based micelles, paclitaxel which is widely used for the treatment of many different types of tumor was used (Fig. 2).21 We prepared 0.5 mg mL 1 solutions of DASA- amphiphile 4 containing 1 mM of paclitaxel (see Fig. S11, ESI†) and incubated MCF-7 cells with this solution for … WebbIt was revealed that different affinities among the drug and the aggregated nanostructures led to increased solubility, which may explain the enhanced dissolution of MC-SDP. … ritesh chhabra intimetec