국내 paclitaxel resistance a549

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August undefined, 2024

WebDosis paclitaxel yang diberikan oleh dokter tergantung pada kondisi kesehatan dan luas permukaan tubuh (LPT) pasien. Secara umum, dosis paclitaxel untuk orang dewasa … http://ir.bjmu.edu.cn/handle/400002259/135151?mode=full

Apatinib reverses paclitaxel-resistant lung cancer cells …

WebOne commonly used line is A549, an epithelial carcinoma derived from a 58 year old male patient, known to be KRAS mutant and EGFR wild type. Lung cancer is the leading cause of cancer-related deaths in the world with non-small cell lung cancer (NSCLC) making up about 85% of all lung cancer cases. WebDec 8, 2024 · The human non-small cell lung cancer cell line A549 and the paclitaxel-resistant cell line A549/Taxol were donated by Prof. Yang from Qiqihar Medical College. All the cells were cultured in RPMI-1640 cell culture medium (Solarbio Science and Technology Co., Ltd., Beijing, China) at 37°C and 5% CO 2. shoproom365

KANK1 regulates paclitaxel resistance in lung …

WebThe cellular uptake, intracellular nanoparticle trajectory, and subsequent cellular events were evaluated after treatment with various PLGA nanocomplexes in human lung cancer A549 cells and A549-derived paclitaxel-resistant A549/T12 cell lines with -tubulin mutation.Results: A549 and A549/T12 cells contain constitutively activated Stat3, and ... WebIntensification of paclitaxel and 5-FU cytotoxicity in A549 and A549-PacR cells by 21α-MMD. The cytotoxicity of 21α-MMD (6.25–100 μM), paclitaxel (12.5–200 μM), and 5-FU … WebNov 14, 2016 · Human lung cancer A549 cells, A549/PTX (paclitaxel-resistant) cells and A549/DDP (cisplatin-resistant) cells were tested. The resistance to cisplatin or paclitaxel was detected... shop roof pitch

Analysis of Differential Expression Proteins of Paclitaxel-Treated …

AMP-activated protein kinase re-sensitizes A549 to paclitaxel

WebThis study aimed to investigate the effect of apatinib on the reversal of paclitaxel (PTX) resistance in A549 lung cancer cells (A549/PTX) and related mechanisms. Materials … WebAug 21, 2014 · Increased resistance to paclitaxel in A549 cells with overexpressed MyD88 To determine the functional consequences of elevated MyD88 expression in lung cancer, MyD88 was overexpressed in A549 lung cancer cells using a lentiviral vector. Overexpression was confirmed by qPCR and immunocytochemistry ( Fig. 1A and B ). shop roof rack from my voltWebJun 9, 2024 · Figure 3 B showed that IC50 values for paclitaxel in A549 and A549/PA cells were 1.23 ± 0.14 and 7.03 ± 0.32 μmol/L, respectively, indicating much higher values for A549/PA cells, whose resistance index (RI) was 5.02. A549/PA cells showed more powerful resistance to paclitaxel ( P < 0.05). shop roof shingles

"WebAug 1, 2024 · (C) A549 cells were treated with different concentration of cisplatin for 12 h, 24 h and 48 h, and western blot determined the expression level of CREB. At least three independent experiments were performed. *P < 0.05, **P < 0.01 and ***P < 0.001 compared with control. (TIF 11383 kb) 13046_2024_1299_MOESM2_ESM.tif(11M) " - 국내 paclitaxel resistance a549

국내 paclitaxel resistance a549

Cisplatin-resistant lung cancer cell–derived exosomes increase ...

WebAbstract Objective To investigate the effect of the SMAC gene on paclitaxel sensitivity and cellular activity in lung adenocarcinoma cells based on the caspase-3/Bcl-2/Bax signaling pathway. Methods A paclitaxel-resistant cell line A549/Taxol was established for lung adenocarcinoma, and the cells were divided into four following groups: pcDNA-NC … WebMar 1, 2024 · Paclitaxel (PTX) is a common antineoplastic drug whose functionality is often restricted by drug resistance. Solute carrier organic anion transporter family member …

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WebNov 29, 2024 · Background Cisplatin plus pemetrexed combination therapy is considered the standard treatment for patients with advanced, non-squamous, non-small-cell lung cancer (NSCLC). However, advanced NSCLC has a 5-year survival rate of below 10%, which is mainly due to therapy resistance. We previously showed that the NSCLC cell … WebMar 4, 2024 · These changes in mitochondria are closely related to anti-tumor drug resistance. In this study, we used the lung adenocarcinoma cell line A549 and its …

WebPaclitaxel resistance in human A549, DU-145, H1299, H1993, H292, H358, H460, LNCaP clone FGC, and PC-3 cell lines and mouse LLC1 cell line and epothilone B resistance in … WebMar 1, 2024 · A549 cells were exposed to PTX at the concentrations of 20 nM, 40 nM, 50 nM, 70 nM, 90 nM, 100 nM for 2 weeks each concentration. 4 months were taken to …

WebEstablishment of A549 paclitaxel-resistant cells in vivo. (a) A suspension of A549 cells was injected subcutaneously into the flank of a nude mouse. When the average tumor volume … WebIn this work, we established paclitaxel-resistant cells (A549-T) from parental cell lines by step-dose selection in vitro. Using methylation chip analysis and transcriptome …

WebScheme 1 Synergistic combination of sodium aescinate stabilized polymer-free twin-like nanoparticles to reverse paclitaxel resistance. (A) Aes was utilized to stabilize hydrophobic PTX and FKA to form polymer-free twin-like PTX-A NPs and FKA-A NPs.(B) With the aid of Aes, these two drugs could accumulate in tumor tissue via passive targeting and be …

WebA549 or paclitaxel-resistant A549 cells were seeded at 3000 cells/well in 96-well plates and cultured overnight. SphK1 specific inhibitor SKI-II, Cisplatin or paclitaxel were then added to the wells at varying concentrations. The cells were further cultured for additional 3 … shoproom.inWebMay 20, 2024 · Cisplatin resistance (CR) was generated in A549 (KRAS) and PC9 (EGFR) cell lines and gene expression was tested. In three-dimensional (3D) multicellular aggregate cultures, both ABCB1 and ABCG2 transporters, as … shop roombahttp://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2024.22.1114 shop roofingWebSilencing USP14 increased the tumor antagonistic action of DDP in A549 cisplatin-resistant (A549/DDP) cells, while USP14 overexpression decreased the antagonist effects. ... and lymphoma. 29 He et al. developed two AMs that selectively bind to two glycoproteins on the surface of a paclitaxel-resistant ovarian carcinoma cell line with high ... shoproom.comWebPTX-resistant (A549- and PC-3-PacR) cells were developed to have transient cross-resistance to 5-fluorouracil (PacR/5-FU), docetaxel (PacR/DCT), and cisplatin (PacR/CIS) by culturing PTX-... shoproomboxWebCell culture and establishment of paclitaxel-resistant A549-Taxol The paclitaxel-resistant A549-Taxol cell line was estab-lished as previously reported. Brieﬂy, the cell lines were … shop room accessoriesWebMar 1, 2024 · A549 cells were exposed to PTX at the concentrations of 20 nM, 40 nM, 50 nM, 70 nM, 90 nM, 100 nM for 2 weeks each concentration. 4 months were taken to construct the resistant cell line called A549-PTX. 2.2.3. CCK8 cell counting assay Cells were seeded into 96-well plates at the density of 3000 cells per well. shop room furniture